For information on current clinical trials, please go to http://clinicaltrials.gov/ and type in “MM-111″ in the search box.
MM-111 is a bispecific antibody designed to target cancer cells that are characterized by overexpression of the ErbB2 cell surface receptor, also referred to as HER2. A bispecific antibody is a type of antibody that is able to bind to two distinct proteins or epitopes. Merrimack’s Network Biology approach identified that ligand-induced signaling through the complex of ErbB2 (HER2) and ErbB3 is a more powerful and widespread promoter of tumor growth and survival than previously appreciated. Merrimack believes that MM-111 is potentially applicable across a broad range of solid tumors. Merrimack is conducting multiple Phase 1 clinical trials of MM-111 in monotherapy and combination therapy settings.